Child’s Play is a great charity that collects “toys, games, books and cash for sick kids in children’s hospitals across North America and the world.”
They seem to focus on providing games to help sick kids deal with being sick and in the hospital. One thing I really like is that they really focus on eliminating the middle man (them) as much as possible and just getting donations straight to the hospitals/children.
On their website, you can choose which hospital (local or otherwise) you’d like to donate to. They take you to an amazon wishlist/registry page and you can donate and have the items shipped right to the hospital.